SALVADOR PANCORBO, PHARM, D., PH.D.; CHRISTINA COMTY, M.D.
To the editor: The weekly clearance of small and middle molecules in patients undergoing continuous ambulatory peritoneal dialysis has been shown to be higher than that in chronic intermittent peritoneal dialysis. Studies have shown clearances of vitamin B12 in patients undergoing continuous ambulatory peritoneal dialysis to be more than three times those reported for chronic intermittent peritoneal dialysis (1). Many patients undergoing continuous ambulatory peritoneal dialysis need digoxin for management of congestive heart failure or atrial arrhythmias. The clearance of digoxin in patients undergoing intermittent peritoneal dialysis has been reported to be about 8 mL/min (2). These values are considered
PANCORBO S, COMTY C. Digoxin Pharmacokinetics in Continuous Peritoneal Dialysis. Ann Intern Med. ;93:639. doi: 10.7326/0003-4819-93-4-639_1
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Published: Ann Intern Med. 1980;93(4):639.
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