MATTHEW A. MOVSESIAN, M.D.; JOHN M. MERRILL, M.D.
To the editor: Eosinophilia occurs in various clinical conditions; its mechanisms are poorly understood (1). We describe here a peripheral eosinophilia occurring without other hematologic or serologic abnormalities in a patient treated with dacarbazine (DTIC), with the eosinophilia appearing to represent an idiosyncratic-allergic drug reaction.
A 65-year-old woman with no history of allergies developed an inguinal mass 7 years after excision of a superficial spreading melanoma from her left calf. Biopsy showed recurrent tumor, and subsequent examination did not reveal systemic disease. She had a leukocyte count of 8100/mm3 with a normal differential (absolute eosinophil count 160/mm3), hematocrit of 33.9%
MOVSESIAN MA, MERRILL JM. Eosinophilia with DTIC Chemotherapy. Ann Intern Med. ;93:642–643. doi: 10.7326/0003-4819-93-4-642
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Published: Ann Intern Med. 1980;93(4):642-643.
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