STEVEN J. ROSANSKY, M.D.; MARK KENNEDY, M.D.
To the editor: Sickle cell anemia is associated with tubulointerstitial renal dysfunction, which results in abnormal water conservation in patients with sickle cell disease (SS) and sickle cell trait (SA), and incomplete distal renal tubular acidosis (1) and impaired renal tubular potassium secretion (2) in SS patients. Normal renal acidification has been reported in SA patients (3). To our knowledge, type IV renal tubular acidosis has not been reported in association with sickle cell anemia. We describe a patient with sickle cell trait and type IV renal tubular acidosis secondary to interstitial renal disease who presented with recurrent episodes of
ROSANSKY SJ, KENNEDY M. Sickle Cell Trait with Episodic Acute Renal Failure and Type IV Renal Tubular Acidosis. Ann Intern Med. 1980;93:643. doi: 10.7326/0003-4819-93-4-643_1
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Published: Ann Intern Med. 1980;93(4):643.
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