ESKlLD A. PETERSEN, M.D.; DAVID W. ALLING, M.D.; CHARLES H. KIRKPATRICK, M.D.
Twelve patients with chronic mucocutaneous candidiasis were assigned by random allocation to a 6-month course of treatment with ketoconazole or placebo in a double-blind trial. All six recipients of ketoconazole had remission of symptoms and virtually complete regression of mucosal, skin, and nail lesions, whereas only two of the six receiving placebo had even temporary mucosal clearing, and none had improvement of skin or nail disease. The clinical outcome in the ketoconazole-treated group was significantly more favorable (p 0.001) than in the placebo-treated group. The six patients receiving placebo in the controlled trial were then treated with ketoconazole in an open trial, and all responded favorably. Hepatitis, probably drug induced, developed in one patient after 6 months of treatment but proved to be mild and reversible. Oral ketoconazole is an effective treatment for chronic mucocutaneous candidiasis.
PETERSEN EA, ALLING DW, KIRKPATRICK CH. Treatment of Chronic Mucocutaneous Candidiasis with Ketoconazole: A Controlled Clinical Trial. Ann Intern Med. 1980;93:791–795. doi: 10.7326/0003-4819-93-6-791
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Published: Ann Intern Med. 1980;93(6):791-795.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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