LAWRENCE E. SAMELSON, M.D.; STEPHEN A. LERNER, M.D.; LEON RESNEKOV, M.D.; CONSTANTINE ANAGNOSTOPOULOS, M.D.
Fungal endocarditis responds poorly to medical therapy (1, 2). Therapeutic recommendations now include early surgery and aggressive use of antifungal drugs (3, 4). With increasing numbers of reports of late relapses, the definition of cure has now come into doubt (2, 5). We describe here a case of Candida parapsilosis endocarditis in a patient who relapsed after 7 years of suppressive therapy with flucytosine.
A 36-year-old female heroin abuser developed C. parapsilosis mitral valve endocarditis in September 1970. She needed excision of the infected valve and replacement with a #27 Björk-Shiley mitral valve prosthesis. After surgery the patient received 1.12
SAMELSON LE, LERNER SA, RESNEKOV L, ANAGNOSTOPOULOS C. Relapse of Candida parapsilosis Endocarditis After Long-Term Suppression with Flucytosine: Retreatment with Valve Replacement and Ketoconazole. Ann Intern Med. ;93:838–839. doi: 10.7326/0003-4819-93-6-838
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Published: Ann Intern Med. 1980;93(6):838-839.
Cardiology, Endocarditis, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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