RALPH LAZZARA, M.D.; BENJAMIN SCHERLAG, PH.D.
In the past 20 years there have occurred the discovery and avid study of the "slow current," an inward flow of positive ions, predominantly calcium, across the sarcolemma of cardiac cells throughout most of systole (1). This ion flux is a prime factor in the initiation of contraction and contributes to the regulation of the intensity and duration of contraction. The slow current is distinguished from the "rapid current" of sodium ions, which enters the cells as an intense brief surge during the upstroke of the action potential and provides the excitatory current for normal propagation of the impulse. The
LAZZARA R, SCHERLAG B. Treatment of Arrhythmias by Blocking Slow Current. Ann Intern Med. 1980;93:919–921. doi: 10.7326/0003-4819-93-6-919
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Published: Ann Intern Med. 1980;93(6):919-921.
Cardiology, Rhythm Disorders and Devices.
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