ELLEN D. BURGESS, M.D.; PATRICK N. FRIEL, B.S.; ANDREW D. BLAIR Jr., Ph.D.; VIDMANTAS A. RAISYS, Ph.D.
Several techniques have been established for ascertaining serum phenytoin concentrations. The simplest technique, which is most widely used, is the enzyme-multiplied immunoassay (EMIT; Syva Corporation, Palo Alto, California), a nonradioactive immunoassay based on the enzymatic activity of a hapten-enzyme conjugate that is influenced by the hapten-antibody reaction (coefficients of variation less than 10%). Many studies have shown excellent statistical agreement between the enzyme-multiplied immunoassay and the more traditional gas-liquid chromatography and high-performance liquid chromatography methods (coefficients of variation, 5%) (1, 2). Recent isolated reports suggest that the enzyme-multiplied immunoassay is not accurate in the presence of renal failure (3, 4).
ELLEN D. BURGESS, PATRICK N. FRIEL, ANDREW D. BLAIR, VIDMANTAS A. RAISYS. Serum Phenytoin Concentrations in Uremia. Ann Intern Med. 1981;94:59–60. doi: 10.7326/0003-4819-94-1-59
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Published: Ann Intern Med. 1981;94(1):59-60.
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