ELLEN D. BURGESS, M.D.; PATRICK N. FRIEL, B.S.; ANDREW D. BLAIR Jr., Ph.D.; VIDMANTAS A. RAISYS, Ph.D.
Several techniques have been established for ascertaining serum phenytoin concentrations. The simplest technique, which is most widely used, is the enzyme-multiplied immunoassay (EMIT; Syva Corporation, Palo Alto, California), a nonradioactive immunoassay based on the enzymatic activity of a hapten-enzyme conjugate that is influenced by the hapten-antibody reaction (coefficients of variation less than 10%). Many studies have shown excellent statistical agreement between the enzyme-multiplied immunoassay and the more traditional gas-liquid chromatography and high-performance liquid chromatography methods (coefficients of variation, 5%) (1, 2). Recent isolated reports suggest that the enzyme-multiplied immunoassay is not accurate in the presence of renal failure (3, 4).
BURGESS ED, FRIEL PN, BLAIR AD, RAISYS VA. Serum Phenytoin Concentrations in Uremia. Ann Intern Med. ;94:59–60. doi: 10.7326/0003-4819-94-1-59
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Published: Ann Intern Med. 1981;94(1):59-60.
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