R. PEREZ-SOLER, M.D.; R. ESTEBAN, M.D.; J. GUARDIA, M.D.
To the editor: The paper by Border and Cohen (1) reported four cases of clinically silent myeloma presenting as acute renal failure and diagnosed by renal biopsy. We were very surprised that no mention was made of what is a rather exceptional feature. Multiple myeloma may present, although rarely, as acute renal failure. The finding of an M-protein in the serum protein electrophoresis makes renal biopsy unnecessary in most cases. In Bence-Jones myeloma, however, as no M-protein is found in serum and the usual hypogammaglobulinemia may not be readily taken into account, renal biopsy in some cases may not be
PEREZ-SOLER R, ESTEBAN R, GUARDIA J. Urinary Monoclonal Immunoglobulin in Multiple Myeloma. Ann Intern Med. ;94:140. doi: 10.7326/0003-4819-94-1-140_2
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Published: Ann Intern Med. 1981;94(1):140.
Hematology/Oncology, Multiple Myeloma.
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