SWEE LAY THEIN, B.M., B.S.; JOHN M. GOLDMAN, B.M.; DAVID A. G. GALTON, M.D.
Four cases of acute graft-versus-host disease have now been reported in patients who have received transplants of syngeneic bone marrow (1, 2). This phenomenon could be explained if graft-versus-host disease were due to an imbalance of lymphocyte subsets regardless of donor-recipient histocompatibility (3). We have recently seen a patient with chronic granulocytic leukemia in transformation who developed a syndrome resembling acute
Figure 1. Clinical and hematological course of patient with "graft-versus-host disease." DNR = daunorubicin; Ara-C = cytarabine; 6TG = 6-thioguanine; platelets = donor platelet transfusions (irradiated to 1500 rad); WBC = donor granulocyte transfusions (irradiated to 1500 rad); Hb = hemoglobin; BM = bone marrow biopsies; CP = chronic phase.
graft-versus-host disease after autografting with stored buffy-coat leukocytes.
A 23-year-old woman was found to have Philadelphia-chromosome-positive chronic granulocytic leukemia in August 1978. Peripheral blood cells were collected by leukapheresis and cryopreserved. She was treated with busulphan, and splenectomy was
THEIN SL, GOLDMAN JM, GALTON DAG. Acute "Graft-Versus-Host Disease" After Autografting for Chronic Granulocytic Leukemia in Transformation. Ann Intern Med. ;94:210–211. doi: 10.7326/0003-4819-94-2-210
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Published: Ann Intern Med. 1981;94(2):210-211.
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