P. N. DURRINGTON, M.D.; J. E. MacIVER, M.D.; G. HOLDSWORTH, Ph.D.; D. J. GALTON, M.D.
Both type I and type V hyperlipoproteinemia are characterized by hyperchylomicronemia (1). In type I hyperlipoproteinemia levels of no other serum lipoproteins are increased, whereas in type V hyperlipoproteinemia very low density lipoprotein levels are also elevated. Recognized complications of both disorders include episodes of abdominal pain, acute pancreatitis, splenomegaly, and splenic infarction (1). We report a middle-aged patient with the type V phenotype who was unusual because she had pancytopenia secondary to hypersplenism, a complication previously believed not to occur with splenomegaly due to hyperchylomicronemia (1). She also had a profound deficiency of lipoprotein lipase activity in both postheparin
DURRINGTON PN, MacIVER JE, HOLDSWORTH G, GALTON DJ. Severe Hypertriglyceridemia Associated with Pancytopenia and Lipoprotein Lipase Deficiency. Ann Intern Med. 1981;94:211–212. doi: 10.7326/0003-4819-94-2-211
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Published: Ann Intern Med. 1981;94(2):211-212.
Cardiology, Coronary Risk Factors, Dyslipidemia, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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