VINCENT AGNELLO, M.D.
The C1q precipitin test, in which the C1q component was used in gel diffusion to detect gamma globulin complexes in pathologic body fluids, was described 10 years ago (1). The limitations of the technique were clearly defined at the outset. Although the C1q reagent reacted preferentially with complexed antibody, regardless of the antigen involved, it did not differentiate antigen-antibody complexes from nonspecifically aggregated immunoglobulins. Moreover, it reacted with various polyanions. Nonetheless, this approach was attractive to clinical investigators, because in most human diseases in which immune complexes had been implicated in the pathologic process the antigen involved was unknown. Hence,
AGNELLO V. Immune Complex Assays: The First Ten Years. Ann Intern Med. ;94:266–267. doi: 10.7326/0003-4819-94-2-266
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Published: Ann Intern Med. 1981;94(2):266-267.
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