YORAM LEVO, M.D.
To the editor: The relation between hepatitis B virus (HBV) and essential mixed cryoglobulinemia is controversial. We have found evidence of prior exposure to HBV in 74% of the examined patients (1), whereas Popp and colleagues (2) found such evidence in only one of their 12 patients. In the August issue Dienstag and associates (3) suggested that a sampling bias may have accounted for this discrepancy. I believe that their assumption is correct and that their series did not reflect "typical" patients with essential mixed cryoglobulinemia. Their group not only had an unusual sex ratio of females to males of
LEVO Y. Hepatitis B Virus and Essential Mixed Cryoglobulinemia. Ann Intern Med. ;94:282. doi: 10.7326/0003-4819-94-2-282_1
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Published: Ann Intern Med. 1981;94(2):282.
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