STEVEN J. HOORNTJE, M.D.; ERIK J. L. PRINS, M.D.; ANDRIES J. SMIT, M.D.; AB J. M. DONKER, M.D.
Various diseases, including the hemolytic uremic syndrome, produce renal functional changes by compromising renal circulation. Narrowing of the arteriolar lumen can lead to hypertension in a manner analogous to the Goldblatt mechanism (1). This condition may be managed successfully by blockade of the renin-angiotensin system (2).
We report reversal of hypertension and renal failure by captopril in a patient with the hemolytic uremic syndrome. A second attack occurred during captopril treatment shortly after the patient accidentally reinstituted use of the same oral contraceptive she had used before the first attack.
A 17-year old woman was admitted in 1977 because of
HOORNTJE SJ, PRINS EJL, SMIT AJ, DONKER AJM. Reversal of Long-Standing Renal Insufficiency by Captopril in a Patient with Relapsing Hemolytic Uremic Syndrome Due to an Oral Contraceptive. Ann Intern Med. ;94:355–357. doi: 10.7326/0003-4819-94-3-355
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Published: Ann Intern Med. 1981;94(3):355-357.
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