GARY E. WHEELER, M.D.
The efficacy of cyclophosphamide therapy in Wegener's granulomatosis is well established. Recent reports have suggested other vasculitides may also be responsive to this drug (1, 2). Long-term follow-up studies of patients with Wegener's granulomatosis have not found significant toxicity from continuous cyclophosphamide therapy (3, 4). A patient with Wegener's granulomatosis in whom the development of acute leukemia appears related to cyclophosphamide therapy is described here.
A 53-year-old woman was seen in November 1978 with a 6-week history of arthritis of the second proximal interphalangeal joint of the left hand, the third proximal interphalangeal joint of the right foot, a 7.7
WHEELER GE. Cyclophosphamide-Associated Leukemia in Wegener's Granulomatosis. Ann Intern Med. ;94:361–362. doi: 10.7326/0003-4819-94-3-361
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Published: Ann Intern Med. 1981;94(3):361-362.
Autoimmune Kidney Disease, Hematology/Oncology, Interstitial Lung Disease, Leukemia/Lymphoma, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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