JOHN FEELY, M. D.; IAN H. STEVENSON, Ph.D.; JAMES CROOKS, M.D.
The pharmacokinetics of oral propranolol were studied during chronic treatment in six patients when thyrotoxic and again when euthyroid. The mean total plasma propranolol steady-state concentration was 42% lower when the patients were thyrotoxic. After treatment of thyrotoxicosis there was a fall (p < 0.05) in the oral clearance of both total (4.2 ± 0.6 to 2.7 ± 0.4 L/min, mean ± SEM) and free (30.5 ± 4.7 to 25.5 ± 4.1 L/min) propranolol although the half-life of propranolol did not change significantly. The free fraction of propranolol was higher (p < 0.05) in the thyrotoxic (14.2% ± 1.3%) than in the euthyroid (11.4% ± 0.8%) state. These results suggest that the pharmacokinetics of propranolol are significantly altered in thyrotoxicosis.
FEELY J, STEVENSON IH, CROOKS J. Increased Clearance of Propranolol in Thyrotoxicosis. Ann Intern Med. ;94:472–474. doi: 10.7326/0003-4819-94-4-472
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Published: Ann Intern Med. 1981;94(4_Part_1):472-474.
Cardiology, Coronary Risk Factors, Endocrine and Metabolism, Hypertension, Nephrology.
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