ALFRED J. SAAH, M.D.; GEORGE L. DRUSANO, M.D.; JOHN W. WARREN, M.D.; JAMES H. TENNEY, M.D.; ELLIS S. CAPLAN, M.D.
Infections associated with the gastrointestinal tract, such as intra-abdominal abscesses, are usually caused by a mixture of facultative or aerobic gram-negative bacilli and anaerobic organisms, particularly Bacteroides fragilis (1). Cefoxitin, a newly introduced cephalosporin-like antibiotic, has a broad spectrum of activity against aerobic gram-negative rods (2) and anaerobic bacteria including the B. fragilis group (3). Because of this range of activity, cefoxitin has been viewed as potentially useful as a single antibiotic in treating mixed aerobic-anaerobic infections of the abdomen (4). Indeed, in a rat model of abdominal abscesses, the effect of cefoxitin alone was equivalent to that of the
SAAH AJ, DRUSANO GL, WARREN JW, TENNEY JH, CAPLAN ES. Cefoxitin-Resistant Facultative or Aerobic Gram-Negative Bacilli in Infections Associated with the Gastrointestinal Tract. Ann Intern Med. ;94:487–488. doi: 10.7326/0003-4819-94-4-487
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Published: Ann Intern Med. 1981;94(4_Part_1):487-488.
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