ALFRED J. SAAH, M.D.; GEORGE L. DRUSANO, M.D.; JOHN W. WARREN, M.D.; JAMES H. TENNEY, M.D.; ELLIS S. CAPLAN, M.D.
Infections associated with the gastrointestinal tract, such as intra-abdominal abscesses, are usually caused by a mixture of facultative or aerobic gram-negative bacilli and anaerobic organisms, particularly Bacteroides fragilis (1). Cefoxitin, a newly introduced cephalosporin-like antibiotic, has a broad spectrum of activity against aerobic gram-negative rods (2) and anaerobic bacteria including the B. fragilis group (3). Because of this range of activity, cefoxitin has been viewed as potentially useful as a single antibiotic in treating mixed aerobic-anaerobic infections of the abdomen (4). Indeed, in a rat model of abdominal abscesses, the effect of cefoxitin alone was equivalent to that of the
ALFRED J. SAAH, GEORGE L. DRUSANO, JOHN W. WARREN, JAMES H. TENNEY, ELLIS S. CAPLAN. Cefoxitin-Resistant Facultative or Aerobic Gram-Negative Bacilli in Infections Associated with the Gastrointestinal Tract. Ann Intern Med. 1981;94:487–488. doi: 10.7326/0003-4819-94-4-487
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Published: Ann Intern Med. 1981;94(4_Part_1):487-488.
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