HAROLD A. HARVEY, M.D.; ALLAN LIPTON, M.D.; BELLARMINE V. LAWRENCE, M.D.
To the editor: In their excellent review, "Hypersensitivity Reactions to Cancer Chemotherapeutic Agents" Weiss and Bruno (1) point out that such reactions are generally rare but may be life threatening and have received little attention in the literature. We report two examples not mentioned by the authors.
Weiss and Bruno cite several examples of severe anaphlactic reactions to intravenous melphalan and state that oral melphalan has produced only minor rashes in a few patients. Because the use of intravenous melphalan is still experimental and quite restricted, we believe a serious reaction to oral melphalan is noteworthy. We have previously reported
HARVEY HA, LIPTON A, LAWRENCE BV. Raynaud's Phenomenon with Vinblastine and Bleomycin. Ann Intern Med. ;94:542–543. doi: 10.7326/0003-4819-94-4-542_2
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Published: Ann Intern Med. 1981;94(4_Part_1):542-543.
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