BRUCE C. MCLEOD, M.D.; RICHARD J. SASSETTI, M.D.; JOAN H. WEENS, M.D.; THIRU VAITHIANATHAN, M.D.
To the editor: Transfusing ABO-incompatible plasma in small amounts has long been considered permissible because the antibody dose will be limited and will be "diluted" in a large pool of erythrocytes (1). We have recently seen an exception to this rule: a hemolytic transfusion reaction after administration of a small quantity of incompatible plasma in a platelet concentrate.
A 45-year-old A1 Rh0, (D) positive man had pancytopenia after chemotherapy for erythroleukemia. He had received group A erythrocytes, groups A and AB plasma, and platelet concentrates (including some from donors of groups O and B) without incident. He had been moderately
MCLEOD BC, SASSETTI RJ, WEENS JH, VAITHIANATHAN T. Hemolytic Reaction to a Platelet Concentrate. Ann Intern Med. ;94:543. doi: 10.7326/0003-4819-94-4-543_1
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Published: Ann Intern Med. 1981;94(4_Part_1):543.
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