JAMES B. PUCKETT, M.D.; M. ROBERT COOPER, M.D.
To the editor: We recently reported to this journal the case of a patient in whom acute myelofibrosis developed 3 years after successful multimodality therapy of a non-Hodgkin's lymphoma (1). This patient subsequently showed a gradual evolution into acute myeloblastic leukemia.
A 54-year-old woman developed acute myelofibrosis in April 1980, 3 years after successful multimodality therapy for a diffuse mixed lymphocytic-histiocytic gastric lymphoma. The myelofibrosis was treated with exymetholone and prednisone without improvement. She required weekly erythrocyte and platelet transfusions. Her initial marrow and peripheral smears showed no myeloblastic activity. In July 1980, a repeat bone marrow biopsy showed myelofibrosis
PUCKETT JB, COOPER MR. Acute Myelofibrosis Evolving into Acute Myeloblastic Leukemia. Ann Intern Med. ;94:545–546. doi: 10.7326/0003-4819-94-4-545_3
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Published: Ann Intern Med. 1981;94(4_Part_1):545-546.
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