VICENTE GARCIA, M.D.; JESÚS SAN MIGUEL, M.D.; ANTONIO LÓPEZ BORRASCA, M.D.
To the editor: Experience with chemotherapeutic agents during human pregnancy is limited. We could find only seven references (1-5) to the use of doxorubicin during pregnancy. In all cases the administration was after the 20th week of pregnancy. There is no clinical evidence that the developing fetus was damaged in the cases published. We report here the case of a patient and her fetus in which polyhemotherapy including doxorubicin was given in the first trimester of pregnancy.
A 25-year-old woman was admitted in December 1979 with complaints of sweating, weight loss, fever, and cervical and abdominal lymphadenopathy. Biopsy confirmed the
GARCIA V, SAN MIGUEL J, BORRASCA AL. Doxorubicin in the First Trimester of Pregnancy. Ann Intern Med. 1981;94:547. doi: 10.7326/0003-4819-94-4-547_1
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Published: Ann Intern Med. 1981;94(4_Part_1):547.
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