DAVID L. PAGE, M.D.
To the editor: The responsiveness of some undifferentiated, malignant epithelial neoplasms to a chemotherapeutic protocol designed for germ cell neoplasms (1) is interesting and clinically useful. Assuming, however, that they are (or should even be called) neoplasms of germ cell origin because they respond to such a protocol and because they contain oncofetal antigens is not warranted. Such a posture supposes knowledge where there is little to be had. Undifferentiated neoplasms have perplexed students of tumor biology and classification for generations. We should confess our ignorance and call undifferentiated malignant neoplasms just that until we gain sufficient wisdom to reorder
DAVID L. PAGE. Undifferentiated Malignant Neoplasms. Ann Intern Med. 1981;94:710–711. doi: 10.7326/0003-4819-94-5-710_2
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Published: Ann Intern Med. 1981;94(5):710-711.
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