MICHAEL H. ALDERMAN, M.D.; MARGARET E. STANBACK, M.P.H.
To the editor: The elegant study reported by Grimm and colleagues (1) on "Effects of Thiazide Diuretics on Plasma Lipids and Lipoproteins in Mildly Hypertensive Patients" in the January 1981 issue confirms previous findings (2-5) that, in the short term, diuretic therapy is associated with increases in total serum cholesterol and lipid fractions (low-density lipoproteins [LDL] and very low density lipoproteins [VLDL]). Moreover, the authors present a new observation that high-density lipoprotein (HDL) levels modestly rise (not significant) among patients on diuretic therapy in 6 weeks of treatment.
But although the findings of this thorough and well-designed study are in
ALDERMAN MH, STANBACK ME. Diuretics and Blood Lipids. Ann Intern Med. ;94:822–823. doi: 10.7326/0003-4819-94-6-822_3
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Published: Ann Intern Med. 1981;94(6):822-823.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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