RUTH L. BERKELMAN, M.D.; SHARON LEWIN, M.D.; JAMES R. ALLEN, M.D.; ROGER L. ANDERSON, Ph.D.; LAWRENCE D. BUDNICK, M.D.; STANLEY SHAPIRO, M.D.; STEPHEN M. FRIEDMAN, M.D.; PETER NICHOLAS, M.D.; ROBERT S. HOLZMAN, M.D.; ROBERT W. HALEY, M.D.
Pseudomonas cepacia was recovered from the blood cultures of 52 patients in four hospitals in New York over 7 months from April through October 1980. Epidemiologic investigation in one hospital indicated that the positive results of blood culture represented pseudobacteremias and implicated a 10% povidoneiodine solution used as an antiseptic and disinfectant (Pharmadine; Sherwood Pharmaceutical Company, Mahwah, New Jersey) as the source of contamination. Physicians who drew blood cultures positive for P. cepacia were more likely to have left povidone-iodine on the skin before venipuncture (p=0.026) and were more likely to have applied povidine-iodine to the blood culture bottle tops and to have left it there while inoculating the blood culture media (p=0.007) than those who drew cultures negative for P. cepacia. Direct inoculation of Pharmadine into brain-heart infusion broth yielded P. cepacia; however, 2 weeks after the first cultures, the same Pharmadine bottles were culture negative. The iodine concentrations of the contaminated Pharmadine solutions were similar to those of 10% povidone-iodine solutions distributed by other manufacturers.
BERKELMAN RL, LEWIN S, ALLEN JR, ANDERSON RL, BUDNICK LD, SHAPIRO S, et al. Pseudobacteremia Attributed to Contamination of Povidone-Iodine with Pseudomonas cepacia. Ann Intern Med. ;95:32–36. doi: 10.7326/0003-4819-95-1-32
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Published: Ann Intern Med. 1981;95(1):32-36.
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