WILLIAM J. MARTIN, PHARM. D.; CHARLES W. LLOYD, PHARM. D.
To the editor: We read with interest Drs. Drake and Hollander's article on antacid neutralizing capacity and cost effectiveness (1). They ascertained the neutralizing capacity of 1 mL of a wide range of antacids using Fordtran's method and calculated the volume of each antacid needed to neutralize 140 meq of a 0.1-N HCL solution. This article leaves the reader, however, with the impression that 140 meq of acid-neutralizing capacity must be achieved for effective treatment of uncomplicated peptic ulcer disease.
Recommendations by Littman and Pine (2), Myhill and Piper (3), and others suggest that the antacid dose be enough to
MARTIN WJ, LLOYD CW. Antacids. Ann Intern Med. ;95:118–120. doi: 10.7326/0003-4819-95-1-118
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Published: Ann Intern Med. 1981;95(1):118-120.
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