CHARLES J. DISKIN, M.D.
To the editor: Recently Messerli and colleagues (1) in an interesting paper related elevated serum uric acid levels to decreased renal blood flow as measured by 131I aminohippurate collections. They concluded that early hypertensive vascular involvement was probably to blame. They neglected to consider, however, that both hippurate and urate depend in part on tubular secretion for elimination in the urine. Aminohippurate is not an accurate measure of renal blood flow if there is a disruption of tubular secretion. Sera from spontaneously hypertensive rats have been shown to inhibit aminohippurate secretion (2). Also, it has been shown that when renal
DISKIN CJ. Uric Acid Levels and Renal Blood Flow. Ann Intern Med. ;95:123–124. doi: 10.7326/0003-4819-95-1-123
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Published: Ann Intern Med. 1981;95(1):123-124.
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