JAMES J. RAHAL JR, M.D.; MICHAEL S. SIMBERKOFF, M.D.
To the editor: Parker and Fossieck (1) have described successful treatment of 35 episodes of staphyloccal endocarditis with a regimen of intravenous antibiotic for 2 weeks followed by oral therapy for 4 weeks. Their criteria for the use of oral therapy after 2 weeks were "defervescence, improvement in clinical status and sterile blood cultures . . . monitored by in vitro determination of serum antibacterial activity." In 31 of 35 episodes, the patients were users of intravenous drugs, and in 31 instances there was evidence of tricuspid valve infection. The clinical course and prognosis of staphylococcal endocarditis are well known
RAHAL JJ, SIMBERKOFF MS. Staphylococcal Endocarditis. Ann Intern Med. ;95:239–240. doi: 10.7326/0003-4819-95-2-239_3
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Published: Ann Intern Med. 1981;95(2):239-240.
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