JACOB D. BITRAN, M.D.
To the editor: Doxorubicin and daunorubicin can cause dose-dependent cardiomyopathy in children and adults (1, 2). Risk factors that predispose patients to cardiomyopathy include advanced age, previous radiotherapy to the mediastinum, and concurrent cyclophosphamide therapy (2). A form of anthracycline-induced cardiomyopathy has also been reported (3). This acute cardiomyopathy may manifest as pericarditis-myocarditis, acute left ventricular dysfunction, arrhythmia, and myocardial infarction (3). The risk factors for this acute anthracycline cardiomyopathy are not well defined; however, large doses of doxorubicin over short periods may predispose patients to this toxicity (4).
Over the past 4 years, five patients have developed acute left
BITRAN JD. Doxorubicin Cardiotoxicity and Melphalan. Ann Intern Med. ;95:243–244. doi: 10.7326/0003-4819-95-2-243_3
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Published: Ann Intern Med. 1981;95(2):243-244.
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