MICHAEL FEIN, M.D.
To the editor: An increasing number of drugs have been identified as causing hypersensitivity pneumonitis (1, 2). Sulindac is a widely used, nonsteroidal, antiinflammatory agent that is responsible for a growing number of complications, including peptic ulcer, rash, aplastic anemia, hepatitis (3), and pancreatitis (4). Smith and Lindberg (5) have described a patient with rheumatoid arthritis who developed a noninfectious pulmonary infiltrate during treatment with sulindac. Within 4 hours of sulindac rechallenge he developed fever and hypotension without described pulmonary complications. The following case implicates sulindac as causing a severe interstitial pneumonitis.
A 76-year-old white woman entered Alta Bates Hospital
FEIN M. Sulindac and Pneumonitis. Ann Intern Med. 1981;95:245. doi: 10.7326/0003-4819-95-2-245_1
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Published: Ann Intern Med. 1981;95(2):245.
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