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A cultural revolution has quietly taken place in the West over the past 2 decades of intensive study of the causes of diarrheal diseases. Improved culture and laboratory techniques now permit etiologic identification of the cause of 50% to 70% of acute diarrhea episodes whereas studies of molecular pathogenesis and pathophysiology have led to the discovery of the cyclic adenosine monophosphate- or guanosine 3'5'-monophosphate- mediated intestinal secretion pathways. The scientific development and introduction of oral rehydration therapy is undoubtedly responsible for the greatest reduction in childhood mortality in the developing nations of any medical advance since the introduction of antimicrobials.
Infections of the Gastrointestinal Tract: Microbiology, Pathophysiology, and Clinical Features.. Ann Intern Med. 1981;95:253. doi: 10.7326/0003-4819-95-2-253_1
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Published: Ann Intern Med. 1981;95(2):253.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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