WILLIAM R. BOWIE, M.D.; E. RUSSELL ALEXANDER, M.D.; JOHN B. STIMSON; JOHN F. FLOYD; KING K. HOLMES, M.D., Ph.D.
We treated 289 men who had nongonococcal urethritis with minocycline, 100 mg once or twice daily for 7 or 21 days. After 21 ± 7 days, urethritis persisted or recurred in 31 (27%) of 114 given 7-day therapy and only nine (8%) of 110 given 21-day therapy (p = 0.0005). However, by 49 ± 14 days, the cumulative percent rate of failure was 31% for 7-day and 30% for 21-day therapy. Thus, 21-day therapy only delayed recurrence. The higher daily dosage did not improve outcome. Urethritis persisted or recurred in 19% of men with initial Chlamydia trachomatis infection. Among men without C. trachomatis, urethritis persisted or recurred in 32% with and 52% without Ureaplasma urealyticum infection (p = 0.03). At follow-up, 79% of cases of persistent or recurrent urethritis were culture negative for C. trachomatis and U. urealyticum. The cause of C. trachomatis-negative, U. urealyticum-negative nongonococcal urethritis, which was least responsive to minocycline therapy, remains uncertain.
WILLIAM R. BOWIE, E. RUSSELL ALEXANDER, JOHN B. STIMSON, JOHN F. FLOYD, KING K. HOLMES. Therapy for Nongonococcal Urethritis: Double-Blind Randomized Comparison of Two Doses and Two Durations of Minocycline. Ann Intern Med. 1981;95:306–311. doi: 10.7326/0003-4819-95-3-306
Download citation file:
Published: Ann Intern Med. 1981;95(3):306-311.
Nephrology, Urological Disorders.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use