W. VINCKEN, M.D.; L. HUYGHENS, M.D.; W. SCHANDEVYL, M.D.; D. VERBEELEN, M.D.; L. CORNE, M.D.
To the editor: Ingestion of even slight quantities of the herbicide paraquat often leads to a fatal outcome within 24 hours due to damage of cell membranes by superoxide ions (O-) with subsequent necrosis of liver, heart, kidneys, and adrenals. The survivor often will develop progressive incapacitating and often fatal respiratory failure within 5 to 10 days, due to diffuse fibrosing alveolitis, with an early "exudative" phase and a subsequent "proliferative" phase leading to alveolar lining cell hyperplasia and interstitial fibrosis.
A 32-year-old patient was admitted to the hospital on 22 June 1980, 3 hours after having deliberately ingested 50
VINCKEN W, HUYGHENS L, SCHANDEVYL W, VERBEELEN D, CORNE L. Paraquat Poisoning and Colchicine Treatment. Ann Intern Med. ;95:391–392. doi: 10.7326/0003-4819-95-3-391_2
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Published: Ann Intern Med. 1981;95(3):391-392.
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