WILLIAM W. STEAD, M.D.
To the editor: The analysis by Taylor and associates (1) of the benefit-risk ratio of recommending isoniazid to persons up to 35 years of age with a positive tuberculin reaction and no other risk factors is interesting and provocative. In the same issue Dr. Comstock has dealt at length with its major defects: minimizing the benefits while exaggerating the potential risk by drawing heavily on the unusual experience in Baltimore during the U.S. Public Health Service trial (2).
The younger the age at which a positive tuberculin reaction is incidentally discovered, the greater is the chance the infection is recent
STEAD WW. Isoniazid Prophylaxis. Ann Intern Med. ;95:393. doi: 10.7326/0003-4819-95-3-393_1
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Published: Ann Intern Med. 1981;95(3):393.
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