FREDERICK L. DUNN, M.D.; ANGEL PIETRI, M.D.; PHILIP RASKIN, M.D.
Plasma lipid and lipoprotein-cholesterol levels were measured in 10 insulin-dependent (Type I) diabetics taking their usual dose of conventionally administered insulin during 6 months of a continuous subcutaneous insulin infusion delivered with a small, portable, battery-powered pump. With this insulin delivery system we were able to provide near normal glucoregulation 24 hours a day for the entire study. This improved glucoregulation resulted in significant reductions in total plasma cholesterol and triglyceride, and very low density and low density lipoprotein-cholesterol levels within 2 to 4 weeks of treatment. These changes persisted for the entire 6 months of observation. High density lipoprotein-cholesterol levels rose significantly after 2 months of treatment and continued to increase during the 6-month study. These changes in plasma lipid and lipoprotein-cholesterol levels in response to treatment with continuous subcutaneous insulin infusion would favorably alter the predicted risk for the development of premature atherosclerosis in these patients.
DUNN FL, PIETRI A, RASKIN P. Plasma Lipid and Lipoprotein Levels with Continuous Subcutaneous Insulin Infusion in Type I Diabetes Mellitus. Ann Intern Med. ;95:426–431. doi: 10.7326/0003-4819-95-4-426
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Published: Ann Intern Med. 1981;95(4):426-431.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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