K. D. POOL, M.D.; HOWARD FEIT, M.D., Ph.D.; JOEL KIRKPATRICK, M.D.
D-penicillamine, a known pyridoxine antagonist (1, 2), is being used with increasing frequency in the treatment of rheumatoid arthritis (3-5). We report here an adverse reaction, a profound sensory and motor neuropathy that responded to the addition of pyridoxine. Because neurologic dysfunction in patients with rheumatoid arthritis can occur as a result of several different forms of peripheral neuropathy the recognition of penicillamine-induced neuropathy may be difficult in these patients and is easily prevented with the use of pyridoxine.
A 55-year-old white woman had a long history of seronegative erosive anodular rheumatoid arthritis. She had sustained involvement of all major
POOL KD, FEIT H, KIRKPATRICK J. Penicillamine-Induced Neuropathy in Rheumatoid Arthritis. Ann Intern Med. ;95:457–458. doi: 10.7326/0003-4819-95-4-457
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Published: Ann Intern Med. 1981;95(4):457-458.
Neurology, Neuropathy, Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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