SEWA S. LEGHA, M.D.; ROBERT S. BENJAMIN, M.D.
To the editor: In their excellent paper "Doxorubicin Cardiotoxicity: Assessment of Late Left Ventricular Dysfunction by Radionuclide Cineangiography," Gottdiener and associates (1) have described persistent left ventricular dysfunction in patients treated with cumulative doses of doxorubicin from 480 to 550 mg/m2 of body surface area. Because the left ventricular dysfunction was persistent at 30 months from the last dose of doxorubicin and sequential studies in 13 patients done 6 to 15 months after initial evaluation showed persistent depression of the average ejection fraction value, the authors concluded that such abnormalities may persist for years.
Although these findings are of interest,
LEGHA SS, BENJAMIN RS. Doxorubicin Toxicity. Ann Intern Med. ;95:520–521. doi: 10.7326/0003-4819-95-4-520
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Published: Ann Intern Med. 1981;95(4):520-521.
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