JOHN A. GALLOWAY, M.D.
To the editor: I wish to comment on the article "U-500 Insulin in the Treatment of Antibody-Mediated Insulin Resistance," by Nathan and colleagues(1). The authors describe three patients with immunologic resistance whose insulin dose was significantly reduced when the patients were treated with U-500 pork neutral regular insulin (NRI). In none of the cases presented was there a clear comparison of U-500 pork with U-100 (NRI) pork insulin, which we think would have been equally efficacious.
For many years my colleagues and I have advocated the use of pork regular insulin for patients with immunologic resistance (2-4). The basis for
GALLOWAY JA. Pork Insulin. Ann Intern Med. ;95:522–523. doi: 10.7326/0003-4819-95-4-522
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Published: Ann Intern Med. 1981;95(4):522-523.
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