F. H. AL-KAWAS, M.D.; L. B. SEEFF, M.D.; R. A. BERENDSON, M.D.; H. J. ZIMMERMAN, M.D.; K. G. ISHAK, M.D.
Allopurinol hepatotoxicity occurred in two patients. Data from the literature suggest that allopurinol can occasionally cause liver injury, particularly in persons receiving diuretic drugs or with compromised renal function. Clinical and laboratory findings are consistent with hepatocellular injury mediated by a hypersensitivity reaction. Most patients recover when the drug is withdrawn; the possible benefits of corticosteroid treatment remain to be established.
AL-KAWAS FH, SEEFF LB, BERENDSON RA, ZIMMERMAN HJ, ISHAK KG. Allopurinol Hepatotoxicity: Report of Two Cases and Review of the Literature. Ann Intern Med. ;95:588–590. doi: 10.7326/0003-4819-95-5-588
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Published: Ann Intern Med. 1981;95(5):588-590.
Emergency Medicine, Gastroenterology/Hepatology, Gout, Liver Disease, Rheumatology.
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