MURRAY L. COHEN, M.D.; ITZHAK KRONZON, M.D.
Primary pulmonary hypertension is a disease of unknown cause that presents with a progressive rise in pulmonary artery pressure leading almost inevitably to the development of right-sided heart failure and death. This disorder occurs most frequently in women during the second and third decade of life (1, 2).
Increased pulmonary vascular resistance associated with an increased pulmonary artery pressure and normal left-sided pressure form the physiologic basis of the diagnosis (2). The decrease in pulmonary vascular resistance in response to vasodilators seen early in the course of the disease is lost as the disease progresses (3). Wagenvoort and Wagenvoort (1)
COHEN ML, KRONZON I. Adverse Hemodynamic Effects of Phentolamine in Primary Pulmonary Hypertension. Ann Intern Med. 1981;95:591–592. doi: 10.7326/0003-4819-95-5-591
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Published: Ann Intern Med. 1981;95(5):591-592.
Pulmonary Hypertension, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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