JOHN A. WASHINGTON II, M.D.
To the editor: The letter by Rajashekaraiah and Rice (1) describing their method of measuring tolerance raises a number of issues. First, penicillinase-resistant penicillins are inconsistently bactericidal to Staphylococcus aureus in trypticase soy broth (2), the medium these authors recommended for measuring tolerance. Second, the statement that S. aureus appears more tolerant to cell wall active antibiotics at concentrations of 50 μg/mL than at those near the minimal inhibitory concentration suggests that the authors have confused tolerance with the paradoxical zone phenomenon described by, among others, Eagle and Musselman (3).
It is customary to define the minimal bactericidal (or lethal)
WASHINGTON JA. Antibiotic Tolerance. Ann Intern Med. ;95:657–658. doi: 10.7326/0003-4819-95-5-657_3
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Published: Ann Intern Med. 1981;95(5):657-658.
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