FREDRIC C. KULLBERG, M.D.; AKIRA FUNAHASHI, M.D.; KENNETH A. SIEGESMUND, Ph.D.
Eosinophilic granuloma is a granulomatous disorder of uncertain cause, manifested by reactive proliferation of histiocytes that may involve the lung either as part of disseminated disease or in a "primary" form, without evidence of other organ involvement (1, 2). The diagnosis of pulmonary eosinophilic granuloma usually requires open lung biopsy, with light microscopic demonstration of nodular, interstitial lung infiltration with histiocytes and eosinophils.
Several authors have reported finding rodlike intracytoplasmic inclusion bodies within histiocytes on electron microscopy of open lung biopsy specimens from patients with pulmonary eosinophilic granuloma (2-5). These cytoplasmic structures, called "X-bodies," are believed to be a characteristic
KULLBERG FC, FUNAHASHI A, SIEGESMUND KA. Pulmonary Eosinophilic Granuloma: Electron Microscopic Detection of X-Bodies on Lung Lavage Cells and Transbronchoscopic Lung Biopsy in One Patient. Ann Intern Med. 1982;96:188–189. doi: 10.7326/0003-4819-96-2-188
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Published: Ann Intern Med. 1982;96(2):188-189.
Interstitial Lung Disease, Pulmonary/Critical Care.
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