DAVID T. KIANG, M.D., PH.D.
To the editor: Tumor estrogen receptor activity has been described in a case of Hodgkin's disease that regressed under estrogen therapy (1), and has also been reported in malignancies of "nonsteroid target tissues," such as melanoma, sarcoma of bones, colon cancer, and renal cell carcinoma. Although these reports are exciting, they also generate great concerns with the method of reporting estrogen receptor activity, which we have emphasized in the past (2). Not all the substances that can bind estradiol are receptors.
After the presence of estrogen receptor activity was shown in human malignant melanoma by the dextran-coated charcoal method (3),
KIANG DT. Estrogen Receptors in Various Tissues. Ann Intern Med. ;96:257–258. doi: 10.7326/0003-4819-96-2-257_3
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Published: Ann Intern Med. 1982;96(2):257-258.
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