LEO R. ZACHARSKI, M.D.
To the editor: Karpatkin and Pearlstein (1) have directed well deserved attention to the interaction between platelets and neoplastic cells. Evidence from experimental tumor sytems suggests that at least certain kinds of neoplastic cells possess the capacity to induce fibrin formation or to sequester platelets; therapeutic blockade of either fibrin formation by means of anticoagulation or platelet activation by means of platelet-inhibitory drugs in different experimental tumor systems has resulted in amelioration of the growth and spread of certain tumors. (ZACHARSKI LR. Biologic basis for anticoagulant treatment of cancer. Submitted for publication.) These findings have led to the hypothesis that
ZACHARSKI LR. Antithrombotic Therapy for Cancer. Ann Intern Med. ;96:258. doi: 10.7326/0003-4819-96-2-258_1
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Published: Ann Intern Med. 1982;96(2):258.
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