SHIMONA YOSSELSON-SUPERSTINE, PHARM.D.; ARTHUR G. LIPMAN, PHARM.D.
To the editor: A possible interaction between benzodiazepine and levodopa has been suggested (1-4) but documentation with challenge and rechallenge has not appeared. We recently observed a profound effect of chlordiazepoxide on the control of parkinsonism; the effect resolved after discontinuation of the benzodiazepine.
A 66-year-old woman who had parkinsonism for 15 years had been treated sucessfully with levodopa, 500 mg six times daily; benztropine mesylate (Cogentin, Merck Sharp & Dohme, West Point, Pennsylvania), 1 mg/d; and diphenhydramine HC1 (Benadryl, Parke-Davis; Morris Plains, New Jersey), 25 mg/d. Recently this patient was diagnosed as having metastatic lung carcinoma, but no chemotherapy
YOSSELSON-SUPERSTINE S, LIPMAN AG. Chlordiazepoxide Interaction with Levodopa. Ann Intern Med. ;96:259–260. doi: 10.7326/0003-4819-96-2-259
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Published: Ann Intern Med. 1982;96(2):259-260.
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