SHELTON W. THOMAS, M.D.
To the editor: Information concerning aminoglycoside penetration into pericardial fluid is limited. Riff and Jackson (1) suggest that gentamicin penetrates into pericardial fluid reaching concentrations approximately one half those found in serum. Accordingly, a patient treated for suppurative pericarditis with an aminoglycoside would be exposed to high drug levels in the serum for an extended period, and nephrotoxicity and ototoxicity could result (2). However, Scherrer and colleagues (3) have shown equal levels of the aminoglycoside tobramycin in serum and exudative pericardial fluid when drawn simultaneously (3). Thus, high serum levels might not be necessary for effective treatment of gram-negative pericarditis.
THOMAS SW. Aminoglycoside Penetration of the Pericardium. Ann Intern Med. ;96:382–383. doi: 10.7326/0003-4819-96-3-382_2
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Published: Ann Intern Med. 1982;96(3):382-383.
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