LEONARD J. LYON, M.D.; JOSE ANTONY, M.D.
Recent experimental (1-2) and clinical (3-7) studies suggest that naloxone hydrochloride, generally considered to be a specific opiate antagonist, can reverse the effects of alcoholic intoxication. We report two cases of coma caused by ethanol; in each case, naloxone therapy aroused the patients promptly. Our observations suggest naloxone is not only useful in patients with opiate toxicity, but also may have broader therapeutic use.
Patient 1: A 20-year-old man was brought unconscious to Bergen Pines County Hospital on 11 August 1980 at 0332 h. On admission, his blood pressure was 128/80 mm Hg and pulse, 96/min; temperature, 35.8 °0C; and
LYON LJ, ANTONY J. Reversal of Alcoholic Coma by Naloxone. Ann Intern Med. ;96:464–465. doi: 10.7326/0003-4819-96-4-464
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Published: Ann Intern Med. 1982;96(4):464-465.
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