STEPHEN W. SANDERS, Pharm.D.; JOHN J. ZONE, M.D.; RODGER L. FOLTZ, Ph.D.; KEITH G. TOLMAN, M.D.; DOUGLAS E. ROLLINS, M.D., Ph.D.
Dapsone (4,4′-diaminodiphenyl sulphone) is used to treat several dermatologie disorders (1) including dermatitis herpetiformis. Due to the chronicity of dermatitis herpetiformis and its frequent onset from age 20 to 40 years, therapy with dapsone may coincide with pregnancy and lactation. We describe an infant who had significant serum concentrations of dapsone and its primary metabolite, monoacetyldapsone, after ingesting breast milk containing dapsone. Both the mother and infant had compensated hemolytic anemia.
Dapsone and monoacetyldapsone were analyzed by high pressure liquid chromatography using a modification of the method of Carr and associates (2). Recrystallized 3,3′-diaminodiphenylsulfone (Pfaltz & Bauer, Inc., Stamford, Connecticut)
SANDERS SW, ZONE JJ, FOLTZ RL, TOLMAN KG, ROLLINS DE. Hemolytic Anemia Induced by Dapsone Transmitted Through Breast Milk. Ann Intern Med. ;96:465–466. doi: 10.7326/0003-4819-96-4-465
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Published: Ann Intern Med. 1982;96(4):465-466.
Hematology/Oncology, Red Cell Disorders.
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