HUNTER HEATH III, M.D.
To the editor: I enjoyed Bilezikian's timely and well-thought-out article on the medical management of primary hyperparathyroidism (1). However, in regard to his remarks on cimetidine and propranolol administration to suppress parathyroid hormone secretion, I believe he is unnecessarily restrained. In my view, there is no reliable evidence to support the use of either agent. More importantly, Rudnick and colleages (2) point out in the same issue that cimetidine can occasionally induce disastrous renal failure. Cimetidine may also impair renal tubular secretion of creatinine (3); in treating normal volunteers and patients with primary and secondary hyperparathyroidism, we found significant increases
HEATH H. Medical Treatment of Primary Hyperparathyroidism. Ann Intern Med. ;96:683–684. doi: 10.7326/0003-4819-96-5-683
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Published: Ann Intern Med. 1982;96(5):683-684.
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