DAVID BAR-OR, M.D.; JOHN A. MARX, M.D.; JAMES T. GOOD JR., M.D.
To the editor: High-altitude pulmonary edema develops in certain unacclimatized and susceptible persons acutely exposed to extreme elevation. Since its original report the clinical manifestations have been well described, but despite numerous speculations the pathogenesis of this disorder remains unclear (1-3).
We describe here an otherwise healthy man who presented with high-altitude pulmonary edema, in whom plasma beta endorphins were measured and found to be significantly elevated. Dramatic improvement in the patient's hypoxemia and clinical course occurred after administration of naloxone. We postulate that this opiate antagonist may be beneficial in the treatment of this disorder.
A 22-year-old white man,
BAR-OR D, MARX JA, GOOD JT. Naloxone, Beta Endorphins, and High-Altitude Pulmonary Edema. Ann Intern Med. ;96:684–685. doi: 10.7326/0003-4819-96-5-684_3
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Published: Ann Intern Med. 1982;96(5):684-685.
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