MAURIE MARKHAM, M.D.; MARTIN D. ABELOFF, M.D.
To the editor: Remote effects of cancer on the nervous system have been well described clinically but the pathophysiologic basis of such events is poorly understood (1-3). Similarly, little information is available on the response of these paraneoplastic syndromes to specific antitumor therapy. We describe a patient with limbic encephalitis secondary to small-cell carcinoma of the lung whose neurologic manifestations reversed dramatically after treatment.
A 45-year-old woman with no history of neurologic dysfunction had the sudden onset of temporal lobe seizures characterized by uncontrolled grimacing, vocalization, disorientation, and bilateral hyperextension of her arms and legs. An electroencephalogram (EEG) showed a
MARKHAM M, ABELOFF MD. Small-Cell Lung Cancer and Limbic Encephalitis. Ann Intern Med. 1982;96:785. doi: 10.7326/0003-4819-96-6-785_1
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Published: Ann Intern Med. 1982;96(6_part_1):785.
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