STEVEN H. COHEN, M.D.; STEVEN L. KAGEN, M.D.
To the editor: Although the primary action of Cimetidine is gastric acid suppression, other effects have been noted related to its H2 antihistamine effect (I)-H2 sites are present in the skin (2), and Cimetidine can cause a mild reduction of histamine-induced wheals and flares (3). The studies cited were done with oral Cimetidine, but evidence from two patients we have seen suggests that this medication may be a more potent skin suppressor when given intravenously.
We were asked to see two patients with a possible penicillin allergy who were in an intensive care unit. Both patients were critically ill and
COHEN SH, KAGEN SL. Cimetidine and Allergy Skin Testing. Ann Intern Med. ;96:787. doi: 10.7326/0003-4819-96-6-787_1
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Published: Ann Intern Med. 1982;96(6_part_1):787.
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